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A mixed fruit and vegetable concentrate increases plasma antioxidant vitamins and folate and lowers plasma homocysteine in men

Samman S et al., Journal of Nutrition, Vol.133, Iss.7, July 2003, pp. 2188–2193

Schwerpunkt dieser Studie war die Untersuchung von Risikofaktoren für Herz-Kreislauf-Erkrankungen unter Einnahme von Juice Plus+® und unter Anwendung eines kontrollierten Studiendesigns. In dieser randomisierten, placebokontrollierten und doppelblinden Studie mit Cross-Over Design, die an gesunden Probanden mit sehr guten Ernährungsparametern durchgeführt wurde, konnte nach 6 Wochen Supplementation ein hochsignifikanter Anstieg von Beta-Karotin und Folsäure, eine Senkung des Serumhomocysteins und eine Erhöhung der Resistenz gegenüber der Oxidation von LDL-Cholesterin aufgezeigt werden. Die Autoren folgerten daraus, dass die Supplementation mit den Obst- und Gemüsekonzentraten Ergebnisse erzielte, die mit einer Reduktion des Risikos für KHK konsistent sind.

Journal of Nutrition (American Society for Nutitional Sciences)



July 2003, Vol. 133, Iss. 7: 2188-2193.

Samir Samman, Gayathri Sivarajah, June C. Man, Ziaul I. Ahmad, Peter Petocz* and Ian D. Caterson



Human Nutrition Unit, School of Molecular and Microbial Biosciences, University of Sydney NSW 2006 and *Department of Mathematical Sciences, University of Technology, Sydney NSW 2007, Australia

Abstract (engl.)

Fruit and vegetable consumption is inversely associated with coronary heart disease (CHD) risk. The aim of the present study was to determine the effect of supplementation with dehydrated juice concentrates from mixed fruit and vegetables on selected plasma vitamins and antioxidant status. We assessed CHD risk by measuring the concentrations of homocysteine, lipids, lipoproteins, glucose and insulin. Men were recruited to participate in a randomized double-blind, crossover trial with 2 periods of 6 wk, separated by a 3-wk wash-out period. Supplementation with the encapsulated mixed extract (Juice Plus) was compared with physically similar placebo capsules. Thirty-two men (13 smokers, 19 nonsmokers) completed the study with a mean compliance of 88%. Compared with placebo, supplementation increased the concentrations of plasma ß-carotene (0.24 ± 0.15 vs. 1.12 ± 0.70 µmol/L; mean ± SD; P < 0.0001), retinol (1.87 ± 0.33 vs. 2.00 ± 0.43 µmol/L; P < 0.05), -tocopherol (16.8 ± 7.3 vs. 19.3 ± 6.8 µmol/L; P < 0.01), ascorbic acid (72.1 ± 19.4 vs. 84.1 ± 13.5 µmol/L; P < 0.002) and folic acid (24.5 ± 10.0 vs. 44.9 ± 16.9 nmol/L; P < 0.0001). Plasma homocysteine was reduced (8.2 ± 1.5 vs. 7.6 ± 1.1; P < 0.05) and inversely related (r = -0.40, P < 0.001) with serum folate concentrations. Plasma vitamin C was positively correlated with the resistance of LDL to oxidation (r = 0.26, P < 0.05) and the plasma ferric reducing/antioxidant power (FRAP) tended to be greater after supplementation than after the placebo period (1125.5 ± 144.1 vs. 1180.3 ± 158.1 µmol/L; P < 0.065). Plasma glucose, insulin and lipid concentrations were unaffected. Responses of smokers and nonsmokers did not differ. In the absence of dietary modification, supplementation with a fruit and vegetable concentrate produced responses consistent with a reduction in CHD risk.