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Juice powder concentrate and systemic blood pressure, progression of coronary artery calcium and antioxidant status in hypertensive subjects: a pilot study

Houston MC et al., eCAM 2007, pp. 1–8; doi:10.1093/ecam/nel108

In dieser Studie, die an der Vanderbilt University in Nashville, Tennessee durchgeführt wurde, ging es um einen tatsächlichen Ursache-Wirkungsnachweis zwischen Obst- und Gemüsekonsum und der Verringerung des KHK-Risikos. Houston konnte erstmals eine Ursache-Wirkungsbeziehung zwischen dem Verzehr eines Pflanzenkonzentrats aus Obst-, Gemüse- und Beerensäften (Juice Plus+® Obst- und Gemüseauslese und Juice Plus+® Beerenauslese) sowie gesundheitsfördernden Effekten auf die Blutgefäße dokumentieren. In einer 2-Jahresstudie konnte Houston zeigen, dass die Kalzifizierung der koronaren Blutgefäße sowie andere Parameter wie Blutdruck und arterielle Compliance bei den Probanden gegenüber einer historischen Kontrollgruppe deutlich günstiger verliefen. 
The Effect of a Phytonutriet Concentrate Powder on Progression of Coronary Artery Calcium, Arterial Compliance, Blood Pressure and Anti-oxidant Status in Human Subjects

Mark C. Houston, MD, MDc, Vanderbilt University School of Medicine,
Editor in Chief of the Journal of the American Nutraceutical Association, Nashville, Tennessee

Abstract (engl.)

Epidemiological and clinical data indicate that consumption of fruits, vegetables and fiber lowers systemic blood pressure (BP) and subsequent cardiovascular events, and reduces the incidence of coronary heart disease (CHD) and myocardial infarction(MI).



The purpose of the first study was to evaluate the effect of a proprietary phytonutrient concentrate powder (PNCP) on systolic and diastolic BP and arterial compliance (AC) in a group of hypertensive and normotensive subjects. Thirty-three (33) male and female normotensive and hypertensive subjects on no antihypertensive medications or stable doses of antihypertensive medications were given 6 capsules daily of PNCP in an open label single treatment cohort, 24 month study. Of the hypertensives, only 23 were on stable doses of medication and included in the analysis of BP effects. Data were analyzed using SYSTAT Version II with repeated measures of ANOVA. AC was measured with the HDI PulseWave CR- 2000. No dietary or activity instructions were given.



PNCP signifi cantly lowered diastolic BP and improved large AC with a non-significant (NS) trend to reduce systolic BP and without changes in body weight (BW). These effects may favorably influence cardiovascular (CV) outcome. (Table 1, page 8)

The purpose of the second study was to evaluate the efficacy of a proprietary phytonutrient concentrate powder (PNCP) on progression of coronary artery calcification (CAC) and calcium score (CS) by the Agatston Method in hypertensive and normotensive subject assessed by electron beam tomography (EBT).

Forty-two (42) male and female normotensive and hypertensive subjects on no anti-lipid medications or antihypertensive medications or stable doses of antihypertensive medications (23 patients) and on no antioxidants or vitamins were given 6 capsules daily of PNCP in an open label, 24 month study. Data were analyzed using 2-tailed, unpaired T-test in patients matched for baseline CS and BP status and equal variance. Study subjects were compared to 285 historical controls from the Tulane EBT database, matched for BP and baseline coronary CS. (Table 2, page 8)



These data document that this PNCP significantly reduces % CS at one and two years as assessed by EBT, and that this progression is slowed even more during the second year.



1 Juice Plus+® Capsules