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Increased free malondialdehyde concentrations in smokers normalise with a mixed fruit and vegetable juice concentrate: a pilot study

Bamonti F et al., Clinical Chemistry and Laboratory Medicine, 2006; 44(4), pp. 391–395

Rauchen ist ein bekannter Faktor zur Produktion großer Mengen freier Sauerstoffradikale. In dieser Arbeit wurde unter Erhebung des Stoffwechselproduktes Malondialdehyd (MDA) einerseits die erhöhte Belastung von Rauchern und andererseits der regulierende Einfluss von Juice Obst- und Gemüseauslese auf erhöhten oxidativen Stress von Rauchern untersucht. Dabei wurden neue Erkenntnisse bzgl. MDA gewonnen, indem man zwischen freiem MDA (entspricht der aktiven und schädigenden Form) und gebundenem MDA (entspricht dem Ausscheidungsprodukt) unterschied. So wurde klar, dass Total-MDA als Parameter zur Erfassung von oxidativem Stress nicht aussagekräftig ist.

Clin Chem Lab Med 2006;44(4):391–395 © 2006 by Walter de Gruyter
Berlin
New York. DOI 10.1515/CCLM.2006.084 2006/279
Increased free malondialdehyde concentrations in smokers normalise with a mixed fruit and vegetable juice concentrate: a pilot study
Fabrizia Bamonti1,*, Cristina Novembrino2, Silvia Ippolito1, Enzo Soresi3, Alberto Ciani1, Silvia Lonati1, Elisabetta Scurati-Manzoni1 and Giuliana Cighetti4



  1. Department of Medical Science,


  2. Department of Surgical Science,

University of Milan, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena,

Fondazione IRCCS, Milan, Italy


  3. Director of Pneumology, Niguarda Hospital, Milan, Italy


  4. Department of Preclinical Sciences, LITA Vialba, University of Milan, Milan, Italy

Abstract (engl.)

Background: Cigarette smoking, a cardiovascular risk factor leading to oxygen free radical formation, is involved in the development of serious pathological conditions. On the other hand, a healthy diet and adequate supplementation can help prevent many diseases. The aim of our study was to evaluate in healthy light smokers the effects of supplementation with mixed fruit and vegetable juice powder concentrate on homocysteine metabolism and oxidative status.

Methods: In this pilot study, 32 healthy volunteers, 16 light smokers and 16 non-smokers, on twice daily supplementation were monitored at time zero and after 30 days. Plasma homocysteine, and serum vitamin B12 and folate concentrations were measured by immunoenzymatic assays; reactive oxygen species, total antioxidant capacity and thiol groups by spectrophotometric methods; and total and free malondialdehyde concentrations by gas chromatography-mass spectrometry with isotopic dilution.

Results: Baseline free malondialdehyde concentrations were significantly higher in smokers than in non-smokers and normalised after 30-day supplementation. Baseline results for all the other parameters remained unchanged after supplementation, with no significant differences between smokers and nonsmokers.

Conclusion: This is the first study showing a significant decrease in free malondialdehyde levels in light smokers after 1-month phytonutrient supplementation.