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Systemic inflammatory load in humans is suppressed by consumption of two formulations of dried, encapsulated juice concentrate

Jin Y et al., Molecular Nutrition Food Research, Vol. 54, 2010, 1–9

Jin und Mitarbeiter haben am Institut für Pharmakologie der Universität von South Carolina, Columbia, USA den Einfluss von Juice Plus+ auf Marker des Entzündungsgeschehens untersucht. In einer randomisierten und placebokontrollierten Doppelblindstudie mit 117 Probanden, aufgeteilt in drei Gruppen, wurde über 60 Tage Juice Plus+ (sowohl Obst und Gemüse als auch Obst, Gemüse und Beeren) supplementiert. Die Entzündungsparameter Monozyten-chemotaktisches Protein 1 (MCP-1), Makrophagen-Entzündungsprotein 1-(MIP-1), Chemokinrezeptor 5 (RANTES) sowie das antioxidative Enzym Superoxiddismutase (SOD) korrelierten dabei negativ mit der Supplementation in den Verum-Gruppen. Die Ergebnisse dieser Studie stehen im Einklang mit Resultaten anderer Forschungsarbeiten, welche bereits die positive Auswirkung von Obst und Gemüse auf Entzündungskrankheiten zeigten. Einmal mehr konnte damit in einer State-of-the-Art Studie aufgezeigt werden, dass Juice Plus+ in der Lage ist, Effekte von Obst und Gemüse nachzuahmen.

Yu Jin1, Xiangli Cui1, Udai P. Singh2, Alexander A. Chumanevich1, Brook Harmon3, Philip Cavicchia3, Anne B. Hofseth1, Venkata Kotakadi1, Brandy Stroud1, Suresh R. Volate1, Thomas G. Hurley3, James R. Hebert3 and Lorne J. Hofseth1
1 Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC, USA
2 Department of Pathology and Microbiology, School of Medicine, University of South Carolina, Columbia, SC, USA
3 Cancer Prevention and Control Program, University of South Carolina, Columbia, SC, USA

Abstract
 (engl.)

Chronic inflammation contributes to an increased risk for developing chronic conditions such as cardiovascular disease, diabetes, and cancer. A high ‘‘inflammatory load’’ is defined as elevated inflammation markers in blood or other tissues. We evaluated several markers of systemic inflammation from healthy adults and tested the hypothesis that two formulations of encapsulated fruit and vegetable juice powder concentrate with added berry powders (FVB) or without (FV) could impact markers of inflammatory load. Using a double-blind, placebo-controlled approach, 117 subjects were randomly assigned to receive placebo, FV, or FVB capsules. Blood was drawn at baseline and after 60 d of capsule consumption. We measured inflammatory markers (high sensitivity C-Reactive Protein, Monocyte Chemotactic Protein-1, Macrophage Inflammatory Protein 1-b, and Regulated upon Activation, Normal T cell Expressed and Secreted), superoxide dismutase, and micronutrients (b-carotene, vitamin C, and vitamin E). Results showed Monocyte Chemotactic Protein-1, Macrophage Inflammatory Protein 1-b, and RANTES levels were significantly reduced and superoxide dismutase and micronutrient levels were significantly increased in subjects consuming both FV and FVB, relative to placebo. Data suggest a potential health benefit by consuming either formulation of the encapsulated juice concentrates through their anti-inflammatory properties.