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Oxidative stress response to aerobic exercise; comparison of antioxidant supplements
Bloomer RJ et al., Medicine & Science in Sports & Exercise, Vol.38, No.6, June 2006, pp. 1098–1105
In dieser Studie im Kontext von Sport wurde Juice Plus+ erstmalig im Vergleich zu anderen Antioxidanzien untersucht. Hintergrund zu dieser Vorgangsweise war die Fragestellung, ob ein komplexes Obst- und Gemüsekonzentrat wie Juice Plus+ einendirekten Vorteil gegenüber einem herkömmlichen Antioxidanziengemisch hat. Dies konnte anhand von oxidierten Proteinen (Carbonylprotein) eindrücklich dargelegt werden. Juice Plus+ hatte dabei, entgegen den Erwartungen der Autoren, denselben protektiven Effekt wie ein Gemisch aus 1g Vitamin C und 400 IE Vitamin E. Da jedoch Vitamingaben in unphysiologisch hohen Dosen zunehmend kritisch gesehen werden, hat die Gabe von Juice Plus+ große Vorteile, da hier die Vitaminkonzentrationen deutlich tiefer liegen. Als Erklärung für den vergleichbaren Effekt schließen die Autoren, dass weitere Antioxidanzien wie sekundäre Pflanzenstoffe aus den Obst- und Gemüsekonzentraten in Synergie mit Vitaminen zu dem positiven Ergebnis geführt haben.
RICHARD J. BLOOMER1, ALLAN H. GOLDFARB2 and MICHAEL J. MCKENZIE2 1Department of Health and Sport Sciences, University of Memphis, Memphis, TN; and 2Exercise Physiology Laboratory, Department of Exercise and Sport Science, University of North Carolina Greensboro, Greensboro, NC
Abstract (engl.)
BLOOMER, R. J., A. H. GOLDFARB, and M. J. MCKENZIE. Oxidative Stress Response to Aerobic Exercise: Comparison of Antioxidant Supplements. Med. Sci. Sports Exerc., Vol. 38, No. 6, pp. 1098–1105, 2006.
Purpose: To compare the effects of two antioxidant formulas on biomarkers of oxidative stress before and after aerobic exercise.
Methods: Aerobically trained men (N = 25) and women (N = 23) were assigned to one of three treatments: 400 IU of vitamin E + 1 g of vitamin C (V; N = 15), a fruit and vegetable juice powder concentrate (FV; N = 16), or a placebo (P; N = 17).Subjects ran for 30 min at 80% VO2max before, after 2 wk of supplementation, and after a 1-wk washout period. Blood samples were taken before and immediately after exercise and analyzed for protein carbonyls (PC), malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG), and vitamins C and E.
Results: The V treatment increased plasma vitamin C and E after 2 wk (P ≤ 0.05), with no change in the FV or P. Postexercise PC values were elevated for all treatments after all exercise bouts (P < 0.0001). Both V and FV attenuated the exercise-induced increase in PC after 2 wk of supplementation (V = 21%, FV = 17%), and after the 1-wk wash out (V = 13%, FV = 6%) compared with P (P < 0.05), with no differences between V and FV. MDA was unaffected by exercise and treatment. A treatment main effect for 8-OHdG was noted, with values for V lower than for FV and P (4.5 ± 2.5, 5.5 ± 2.7, and 6.0 ± 2.5 ng·mL, respectively; P = 0.0002). No exercise session or time main effect was noted for 8-OHdG, suggesting that the lower mean value for the V treatment group was not a result of the supplementation.
Conclusion: These data suggest that V and FV supplementation for 2 wk can attenuate the rise in PC after 30 min of aerobic exercise, even after a 1-wk washout, without an impact on plasma MDA or 8-OHdG.
