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Immunity and antioxidant capacity in humans is enhanced by consumption of a dried, encapsulated fruit and vegetable juice concentrate

Nantz MP et al., The Journal of Nutrition, Vol. 136, No.10, Oct. 2006, pp. 2606–2610

Mit dieser Arbeit, die am Institut für Nutritional Sciences der Universität Florida in Gainesville durchgeführt wurde, konnten nun in einem kontrollierten Design die ersten Ergebnisse aus einer Pilotstudie aus dem Jahre 1999 über den immunmodulierenden Effekt der Nahrungsergänzung mit Juice Plus+ Obst- und Gemüseauslese bestätigt werden. Neben biologischen Parametern des Immunsystems, des antioxidativen Status, von DNA-Schäden, und Entzündungsparametern wurde auch die Anzahl Krankheitstage untersucht. Trotz der relativ kurzen Dauer von 11 Wochen wurden alle diese Parameter positiv beeinflusst.

Nantz MP et al., The Journal of Nutrition, Vol. 136, No.10, Oct. 2006, pp. 2606–2610

Abstract (engl.)

The daily consumption of fruits and vegetables is a common dietary recommendation to support good health. We hypothesized that a commercially available encapsulated fruit and vegetable juice powder concentrate (FVJC) could support functional indices of health due to increased intake of various phytonutrients. This was a double-blind, randomized, placebo-controlled investigation of 59 healthy law students who consumed either FVJC or placebo capsules for 77 d. Blood was collected on d 1, 35, and 77 to examine the number of circulating ab- and gd-T cells, cytokine production, lymphocyte DNA damage, antioxidant status, and levels of carotenoids and vitamin C. A log of illnesses and symptoms was also kept. The FVJC group tended to have fewer total symptoms than the placebo group (p < 0,076). By d 77 there was a 30% increase in circulating gd-T cells and a 40% reduction in DNA damage in lymphocytes in the FVJC group relative to the placebo group. Plasma levels of vitamin C and of b-carotene, lycopene, and lutein increased significantly from baseline in the FVJC group as did plasma oxygen radical absorptive capacity (50%). Interferon-g produced by phorbol-stimulated lymphocytes was reduced 70% in the FVJC group, whereas other cytokines (IL-4, IL-6, transforming growth factor b) were unchanged relative to treatment or time. FVJC consumption during this study period resulted in increased plasma nutrients and antioxidant capacity, reduction in DNA strand breaks, and an increase in circulating gd-T cells.